Royal Air Force Typhoon FGR4s have conducted a mission with French aircraft in a combined operation on an underground arms cache in Syria operated by the Daesh militant organization, as stated by the UK's MoD.
The site, pinpointed through reconnaissance, was thought to be housing weapons and explosive materials, the release indicated, and was located in hills just north of Palmyra in Syria's central region.
"Our aircraft utilized precision-guided Paveway IV munitions to target a number of approach shafts down to the depot... initial indications suggest the strike was effective," the ministry announced.
There was no indication of any civilian impact in the attack late on Saturday and every plane involved made a safe return, the defence officials confirmed.
The British jets were supported by a Voyager tanker plane.
The Islamic State group - also known as the so-called Islamic State - enforced extremist governance over significant areas in both Syria and Iraq until 2019.
"This action shows British leadership, and resolve to work closely with allied nations, to eliminate any resurgence of Daesh and their harmful and extremist ideologies in the area," the British Defence Secretary John Healey stated.
UK warplanes have performed patrols over Syrian airspace to "prevent any attempted resurgence" of Islamic State following its military defeat at the battle of Baghuz in 2019, the authorities noted.
"I extend gratitude to the personnel of the UK armed forces involved in this operation for their professionalism and their bravery," the Defence Secretary added. "They were part of a great many UK service members stationed over Christmas and New Year. This operation, to take out militants who endanger our way of life, demonstrates how UK forces are prepared to act, all year round, ensuring Britain's security domestically and strong abroad."
In December, the US military conducted what it called a "major assault" targeting IS targets in the country, after an attack resulted in the deaths of two American soldiers and a civilian interpreter in Palmyra.
The U.N. estimates Islamic State still boasts between 5,000 and 7,000 militants in both countries.